Cochrane ( is an international organization whose mission is to promote evidence-informed health decision-making by producing high-quality, relevant, accessible systematic reviews and other synthesized research evidence. Since its founding in 1993, Cochrane has played a major role in the development of rigorous methodology for synthesizing evidence on interventions, diagnostic tests and prognosis (Higgins 2011). All systematic reviews prepared by Cochrane are included in the Cochrane Database of Systematic Reviews (accessible through