Are animal studies more than a modern sacrifice ritual?

So, what exactly is the meaning of integrity in the current science surrounding animal studies? Selective publication of results and details of animal studies is not only harmful for animals and science but can also have serious consequences for human patients. The methodology of Systematic reviews is helping to make quality and translation of preclinical studies transparent, thereby providing the information needed to be able to make improvements. See (www.SYRCLE.nl). In the following, examples from real life are discussed, with a discussion of the underlying processes, as well as possible solutions.